|
KMID : 0350519940470010551
|
|
Journal of Catholic Medical College
1994 Volume.47 No. 1 p.551 ~ p.561
|
|
|
Relationships between Estrogen Receptor Expression Elastosis and Pathologic Parameters in Human Breast Carcinoma
|
|
|
|
|
Abstract
|
|
|
Recently estrogen receptor in breast cancer has been frequently used as a prognostic indicator because of its responsiveness to hormonal therapy and its relation with histologic prognostic parameter. However, it is very difficult to perform
comparative
study between histologic grade and expression of estrogen receptor, because this study is mostly done by immunohistochemical assay on frozen-tissue which may induce artifacts. Nowadays, an immunohistochemical staining method in paraffin embedded
tissue
has been applied in many reports. Elastosis in breast cancer has been reported to be related with histologic prognostic parameters and responsiveness to hormonal therapy. However, there are not many studies about the relationship between estrogen
receptor, elastosis and pathologic parameters.
The present study was performed in order to evaluate the relationship between estrogen receptor, elastosis and pathologic parameter, in paraffin-embedded tissue using immunohistochemical stain. Paraffine embedded tumor samples from 30 breast
carcinoma
patients were analyzed by the immunoperoxidase staining for estrogen receptor expression and modified Gomori aldehyde-fuchsin for elastosis grade. The clinico pathological parameters were assessed by age, histological grade(architectural atypia,
nuclear
atypia, mitotic index). Tumor size and lymph node metastasis. The elastosis grade was categorized as grade 0 or 1(low-grade elastosis) and grade 2 or 3(high-grade elastosis). Possible relationship between these two indicies(estrogen receptor
expression
and elastosis grade ) and a number of pathological parameters were investigated in this study.
@ES The results were as follows.
@EN Of the 30 breast carcinoma immunohistochemically stained for estrogen receptor, 12(40.0%) had granular staining in the cytoplasm.
Estrogen receptor positive tumors were associated with age of patients and histologic grade, but not with tumor size and lymph node metastasis.
2. Elastosis grade 0-1 were 14 cases(46.7%) and elastosis grade 2-3 were 16 cases(53.3%). Elastosis grade was associated with age of patients, histologic grade and tumor size not with lymph node metastasis.
3. There was a positive correlation between estrogen receptor expression and elastosis.
In conclusion, there is a significant association between estrogen receptor expression and elastosis and these factors are significantly correlated to histologic grade and age.
This suggests that estrogen receptor expression and elastosis can serve useful pathological prognostic indicator in breast carcinoma.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|